Antigenic variant of swine influenza virus causing proliferative and necrotizing pneumonia in pigs.
Identifieur interne : 001F31 ( Main/Exploration ); précédent : 001F30; suivant : 001F32Antigenic variant of swine influenza virus causing proliferative and necrotizing pneumonia in pigs.
Auteurs : S. Dea [Canada] ; R. Bilodeau ; R. Sauvageau ; C. Montpetit ; G P MartineauSource :
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [ 1040-6387 ] ; 1992.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (immunologie), Axénie, Femelle, Grossesse, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (médecine vétérinaire), Maladies des porcs (anatomopathologie), Maladies des porcs (immunologie), Maladies des porcs (microbiologie), Pneumopathie virale (anatomopathologie), Pneumopathie virale (immunologie), Pneumopathie virale (médecine vétérinaire), Québec, Suidae, Variation des antigènes (immunologie), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification).
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae, Maladies des porcs, Pneumopathie virale.
- immunologie : Antigènes viraux, Infections à Orthomyxoviridae, Maladies des porcs, Pneumopathie virale, Variation des antigènes, Virus de la grippe A.
- isolement et purification : Virus de la grippe A.
- microbiologie : Maladies des porcs.
- médecine vétérinaire : Infections à Orthomyxoviridae, Pneumopathie virale.
- Animaux, Axénie, Femelle, Grossesse, Québec, Suidae.
English descriptors
- KwdEn :
- Animals, Antigenic Variation (immunology), Antigens, Viral (immunology), Female, Germ-Free Life, Influenza A virus (immunology), Influenza A virus (isolation & purification), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (veterinary), Pneumonia, Viral (immunology), Pneumonia, Viral (pathology), Pneumonia, Viral (veterinary), Pregnancy, Quebec, Swine, Swine Diseases (immunology), Swine Diseases (microbiology), Swine Diseases (pathology).
- MESH :
- chemical , immunology : Antigens, Viral.
- geographic : Quebec.
- immunology : Antigenic Variation, Influenza A virus, Orthomyxoviridae Infections, Pneumonia, Viral, Swine Diseases.
- isolation & purification : Influenza A virus.
- microbiology : Swine Diseases.
- pathology : Orthomyxoviridae Infections, Pneumonia, Viral, Swine Diseases.
- veterinary : Orthomyxoviridae Infections, Pneumonia, Viral.
- Animals, Female, Germ-Free Life, Pregnancy, Swine.
Abstract
A new antigenic variant of swine influenza virus was isolated from the lungs of pigs experiencing respiratory problems in 7 different swine herds in Quebec. Pigs of different ages were affected, and the main clinical signs were fever, dyspnea, and abdominal respiration. Coughing was not a constant finding of the syndrome. At necropsy, macroscopic lesions included the overall appearance of pale animals, general lymphadenopathy, hepatic congestion, and consolidation of the lungs. Histopathologic findings were mainly proliferative pneumonia with a significant macrophage invasion, necrotic inflammatory cells in the alveoli and the airways, a marked proliferation of type II pneumocytes, and thickening of the alveolar septae. Fluorescent antibody examination of lungs of sick piglets did not demonstrate porcine parvovirus, transmissible gastroenteritis virus, or encephalomyocarditis virus. However, evidence of the presence of an influenza type A infection was demonstrated by indirect immunofluorescence (IIF) staining using monoclonal antibody directed to nucleocapsid protein (NP) of human type A influenza virus. The virus was isolated either by intra-allantoic inoculation of specific-pathogen-free embryonating hens' eggs or propagation in canine kidney (MDCK) cells in the presence of trypsin. By hemagglutination inhibition tests, no cross-reactivity was demonstrated with human influenza H1N1, H2N2, and H3N2 strains, and infected MDCK cells did not react by IIF with monoclonal antibodies to NP protein of type B influenza virus. The hemagglutination activity of plaque-purified isolates was only partly inhibited by hyperimmune serum produced to subtypes A/Wisconsin/76/H1N1 and A/New Jersey/76/H1N1 of swine influenza virus. Gnotobiotic piglets that were infected intranasally with egg-adapted isolates of this new antigenic variant of swine influenza virus developed the very same type of lesions observed in field cases.
DOI: 10.1177/104063879200400403
PubMed: 1333815
Affiliations:
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Le document en format XML
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Sauvageau</name></author><author><name sortKey="Montpetit, C" sort="Montpetit, C" uniqKey="Montpetit C" first="C" last="Montpetit">C. 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Dea</name><affiliation wicri:level="1"><nlm:affiliation>Centre de recherche en virologie, Institut Armand-Frappier, Université du Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche en virologie, Institut Armand-Frappier, Université du Québec</wicri:regionArea><wicri:noRegion>Université du Québec</wicri:noRegion></affiliation></author><author><name sortKey="Bilodeau, R" sort="Bilodeau, R" uniqKey="Bilodeau R" first="R" last="Bilodeau">R. Bilodeau</name></author><author><name sortKey="Sauvageau, R" sort="Sauvageau, R" uniqKey="Sauvageau R" first="R" last="Sauvageau">R. Sauvageau</name></author><author><name sortKey="Montpetit, C" sort="Montpetit, C" uniqKey="Montpetit C" first="C" last="Montpetit">C. Montpetit</name></author><author><name sortKey="Martineau, G P" sort="Martineau, G P" uniqKey="Martineau G" first="G P" last="Martineau">G P Martineau</name></author></analytic><series><title level="j">Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc</title><idno type="ISSN">1040-6387</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigenic Variation (immunology)</term><term>Antigens, Viral (immunology)</term><term>Female</term><term>Germ-Free Life</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (isolation & purification)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Orthomyxoviridae Infections (veterinary)</term><term>Pneumonia, Viral (immunology)</term><term>Pneumonia, Viral (pathology)</term><term>Pneumonia, Viral (veterinary)</term><term>Pregnancy</term><term>Quebec</term><term>Swine</term><term>Swine Diseases (immunology)</term><term>Swine Diseases (microbiology)</term><term>Swine Diseases (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux (immunologie)</term><term>Axénie</term><term>Femelle</term><term>Grossesse</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (médecine vétérinaire)</term><term>Maladies des porcs (anatomopathologie)</term><term>Maladies des porcs (immunologie)</term><term>Maladies des porcs (microbiologie)</term><term>Pneumopathie virale (anatomopathologie)</term><term>Pneumopathie virale (immunologie)</term><term>Pneumopathie virale (médecine vétérinaire)</term><term>Québec</term><term>Suidae</term><term>Variation des antigènes (immunologie)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Quebec</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Maladies des porcs</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Infections à Orthomyxoviridae</term><term>Maladies des porcs</term><term>Pneumopathie virale</term><term>Variation des antigènes</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigenic Variation</term><term>Influenza A virus</term><term>Orthomyxoviridae Infections</term><term>Pneumonia, Viral</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des porcs</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Pneumonia, Viral</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Germ-Free Life</term><term>Pregnancy</term><term>Swine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Axénie</term><term>Femelle</term><term>Grossesse</term><term>Québec</term><term>Suidae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new antigenic variant of swine influenza virus was isolated from the lungs of pigs experiencing respiratory problems in 7 different swine herds in Quebec. Pigs of different ages were affected, and the main clinical signs were fever, dyspnea, and abdominal respiration. Coughing was not a constant finding of the syndrome. At necropsy, macroscopic lesions included the overall appearance of pale animals, general lymphadenopathy, hepatic congestion, and consolidation of the lungs. Histopathologic findings were mainly proliferative pneumonia with a significant macrophage invasion, necrotic inflammatory cells in the alveoli and the airways, a marked proliferation of type II pneumocytes, and thickening of the alveolar septae. Fluorescent antibody examination of lungs of sick piglets did not demonstrate porcine parvovirus, transmissible gastroenteritis virus, or encephalomyocarditis virus. However, evidence of the presence of an influenza type A infection was demonstrated by indirect immunofluorescence (IIF) staining using monoclonal antibody directed to nucleocapsid protein (NP) of human type A influenza virus. The virus was isolated either by intra-allantoic inoculation of specific-pathogen-free embryonating hens' eggs or propagation in canine kidney (MDCK) cells in the presence of trypsin. By hemagglutination inhibition tests, no cross-reactivity was demonstrated with human influenza H1N1, H2N2, and H3N2 strains, and infected MDCK cells did not react by IIF with monoclonal antibodies to NP protein of type B influenza virus. The hemagglutination activity of plaque-purified isolates was only partly inhibited by hyperimmune serum produced to subtypes A/Wisconsin/76/H1N1 and A/New Jersey/76/H1N1 of swine influenza virus. Gnotobiotic piglets that were infected intranasally with egg-adapted isolates of this new antigenic variant of swine influenza virus developed the very same type of lesions observed in field cases.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bilodeau, R" sort="Bilodeau, R" uniqKey="Bilodeau R" first="R" last="Bilodeau">R. Bilodeau</name><name sortKey="Martineau, G P" sort="Martineau, G P" uniqKey="Martineau G" first="G P" last="Martineau">G P Martineau</name><name sortKey="Montpetit, C" sort="Montpetit, C" uniqKey="Montpetit C" first="C" last="Montpetit">C. Montpetit</name><name sortKey="Sauvageau, R" sort="Sauvageau, R" uniqKey="Sauvageau R" first="R" last="Sauvageau">R. Sauvageau</name></noCountry><country name="Canada"><noRegion><name sortKey="Dea, S" sort="Dea, S" uniqKey="Dea S" first="S" last="Dea">S. Dea</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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